When I want to escape I go to the Marriott Hilton Head.
It's a gorgeous location with direct beach access with a wonderful spa and fitness center.
And it truly allows me to escape responsibilities because much of Hilton Head Island has sporadic cell tower coverage. I can honestly tell my boss that neither my AT&T nor Verizon phone picks up a signal so he can only reach me via landline. And yes, I'm rarely in my room! LOL... darn that lack of Blackberry access pool or beach side.... :-)
If you enjoy Savannah, try The Bohemian or the Mansion at Forsyth. Both are part of Marriott's Autograph collection. We stayed at the Mansion recently.. nice, quiet but within walking distance of the Riverfront nightlife. The Bohemian is right on the Riverfront and we went there for dinner one night. You've got to check out the rooftop bar that wraps around the entire building. Great views and amazing chicken & waffle sliders.