Stay at the Prague Marriott located at V Celnici 8. Great location that is very close to the Old Town Square. You will love Prague! If you do a search on this site, you should find some more info on Prague.
I agreed that you should stay at the Marriott Prague. It located very central and next to "old city". Could service and people. Take at least one day to see the Prague castle and church and take a lot of walks in the old city. Have a nice trip
the Prague Marriott is very nice, right across from a Metro stop. Minutes to Old Town. The most beautiful city I've ever visited. Untouched by WWII, the city is a wonderland and quaint streets, fun restaurants, wonderful Budvar beer, an incredible castle. The Jewish Quarter is a profound experience, don't miss it.
Both the Courtyard at the airport and on the east side of the city are exceptional values as well. Both are new / modern. The Courtyard in the city is with in walking distance of most attractions. It is also right on the subway line which is easy to use.