Reading between the lines, the issue is really the noise from the other guests rather than the contrived neighborhood. The hotel has a responsibility to keep other guests respectable to the needs of all guests - implying this is the problem, not the convenience of housekeeping.
To be "grouped" wouldn't bother me; to be annoyed by others is definitely an issue that I would take up with management.
Why not ask when you check in for a secluded room and explain your non-normal hours? This should also minimize the normal noise of housekeeping in the hallway which you might find disruptive along with other guests normal activity at times when you'd prefer quiet.
I wouldn't think this would be anymore different than requesting a room away from the elevator and ice machine. Or away from the kitchen if you are late sleeper. Or away from a loud nightclub/bar scene?
Usually if you ask and explain the reason behind your request I find the desk clerks to be quite accomodating.