Laguna Cliffs Marriott Resort & Spa is a good getaway and you will enjoy the location very very much. Haven't stayed there as I stayed at the Newport Coast Villas (excellent hotel as well).
Based on friends recommendations: Views are fab!, resort is nested quietly and hidden, so tranguil and relaxing. Spa's are a gem.
Try it out and let us know, I might have to fly the wife out when I am west coast for a week of work.