travelfairy, That is kind of an open question. London or Paris would be easier to answer. It all depends what you want to do, and what time of year that you are going, and how much you want to spend. The nicest place that I have seen down there is the Waldorf however we were there for golf and it was great. Marriott wise we like the World Centre or the Ren at SeaWorld, both of these places are resorts and charge a substantial resort fee, but both very nice. If you are going to Disney primarily and you are going to spend a lot of time at the parks and not a lot of time at the hotel, save some money and stay at any of the places in lake Buena vista, (eg Vista Centre) They all have the usual stuff.
If you are flying in and don't have a car then stay at Disney for the transportation. My favorite there is Riverside which is a moderate but pretty nice.
There are lots of kids at all places and if you are looking for a quiet get away, go to London or Paris.
Definitely depends on what your plans are travelfairy
While Orlando is a small city, much of what people call Orlando isn't actually Orlando so there is quite a distance between things.
If you plan on going to Disney, there are some great hotels in every brand. If you've never stayed before I definitely recommend staying on property. Depending on what your budget for the trip is hotels can range from "meh" to amazing. I recommend the animal kingdom Lodge, or any hotel on the boardwalk. Off property the RitzRitz, JW, world center will likely be your best Marriott options, however, prices add up quick when you add in resort fees and parking daily.
Universal has some pretty nice hotels near it as well, since they have the Loews properties.
Other attractions in Central Florida aren't really known for their hotels.
If you are going to Disney world and have any questions let me know. I'd be happy to help if I csn