I often try going on one of the sight-seeing bus tours that you see in every city -- like the double-decker buses that you can get off and on at various stops. It helps see what places I really want to spend time at -- and others where a quick drive-by is all that you want.
That is great advice! I used to be dead set against "Tourist" buses! But now I do it in each new city I can. At least the one day, on and of ones. There is no better way to get oriented and enjoy the first day for me!