Absolutely, I am based up here in DC, depending on what kind of crowd you are looking for. Folks tend to flock to their own sections of town. When we really want to get after it we head out to Georgetown, intersection of M Street and Wisconsin is a good place to start (Not Metro Accessible). There is a great waterfront there, Capitol Hill is a cool experience either House Side or Senate side, the house side has more bars. Congress won't be in session in October though. Other good spots are midtown DC, GWU Foggy Bottom and Adams Morgan or if you are adventurous head out to VA and hit up the Clarendon/Ballston area. If you are looking for a more sophisticated crowd try Old Town Alexandria VA.
Let me know what kind of crowd you are after and I can better steer you towards them
A great local pub: Fox and Hounds on 17th and R
Late night food: Bistro Francaise in georgetown open past midnight.
Best dinner in town (highly debatable): Chef Geoff's
Breaking it down on a Thursday night - The Front Page in Dupont Circle.
Of course there is much more -- but this is a pretty traveller friendly list.