The St Pancras is great, fun location and good restaurant. County Hall has the best location (for touristy stuff) and the restaurant is fine but the area can be a bit crowded, esp on weekends. The Marriott Park Lane just redid their concierge lounge and it's quite nice as well. St Ermins has old world charm - it's close to the embassies and felt a bit stuffy for my taste, but lovely. The London edition is funky and cool, and the location is good.
Basically you can't go too wrong. I'd pick my top one or two then read other reviews on those specific hotels here - folks are pretty honest and can give you some great insights.
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I don't doubt that, as other members of the community see this post, they'll chime in and share their thoughts.
In the meantime, I found a couple threads that you might find helpful:
Thanks for posting!